MovDisordV3, Main, Exploration, bibRecord, 003C42

Neuropathology of primary restless leg syndrome: Absence of specific τ‐ and α‐synuclein pathology

Identifieur interne : 003C42 ( Main/Exploration ); précédent : 003C41; suivant : 003C43

Neuropathology of primary restless leg syndrome: Absence of specific τ‐ and α‐synuclein pathology

Auteurs : Sean J. Pittock [États-Unis] ; Timothy Parrett [États-Unis] ; Charles H. Adler [États-Unis] ; Joseph E. Parisi [États-Unis] ; Dennis W. Dickson [États-Unis] ; J. Eric Ahlskog [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-06.

RBID : ISTEX:CFA4295AB932B6C85EDDAC9DE2A9E6C7A3BC0057

Descripteurs français

Pascal (Inist)
- Anatomopathologie, Impatience membre inférieur syndrome, Système nerveux pathologie.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Anatomic pathology, Brain (metabolism), Brain (pathology), Female, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Tissue Proteins (metabolism), Nervous system diseases, Neurofibrillary Tangles (metabolism), Neurofibrillary Tangles (pathology), Restless Legs Syndrome (metabolism), Restless Legs Syndrome (pathology), Restless legs syndrome, Spinal Cord (metabolism), Spinal Cord (pathology), Synucleins, alpha-Synuclein, neuropathology, restless legs syndrome, tau Proteins (metabolism), α‐synuclein, τ‐synuclein.
MESH :
- chemical , metabolism : Nerve Tissue Proteins, tau Proteins.
- metabolism : Brain, Neurofibrillary Tangles, Restless Legs Syndrome, Spinal Cord.
- pathology : Brain, Neurofibrillary Tangles, Restless Legs Syndrome, Spinal Cord.
- Aged, Aged, 80 and over, Female, Humans, Immunohistochemistry, Male, Middle Aged, Synucleins, alpha-Synuclein.

Abstract

The neuroanatomical substrate for restless legs syndrome (RLS) is unknown. We identified 4 patients with idiopathic RLS who came to post‐mortem examination, where brain and spinal cord tissue were available for neuropathological assessment. Lewy bodies were not identified and α‐synuclein immunohistochemistry was uniformly negative. Neurofibrillary tangle pathology was variable and nonspecific. These findings suggest that τ‐ or α‐synuclein brain pathology is not a component of primary RLS. Although chronic ischemic changes were found in all 4 cases, these were probably incidental. The absence of diagnostic microscopic brain or spinal cord pathology suggests that the pathologic substrate may be neurochemical or receptor based. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/CFA4295AB932B6C85EDDAC9DE2A9E6C7A3BC0057/fulltext/pdf

DOI: 10.1002/mds.20042

Affiliations:

États-Unis
Arizona, Floride, Minnesota

Le document en format XML

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<front><div type="abstract" xml:lang="en">The neuroanatomical substrate for restless legs syndrome (RLS) is unknown. We identified 4 patients with idiopathic RLS who came to post‐mortem examination, where brain and spinal cord tissue were available for neuropathological assessment. Lewy bodies were not identified and α‐synuclein immunohistochemistry was uniformly negative. Neurofibrillary tangle pathology was variable and nonspecific. These findings suggest that τ‐ or α‐synuclein brain pathology is not a component of primary RLS. Although chronic ischemic changes were found in all 4 cases, these were probably incidental. The absence of diagnostic microscopic brain or spinal cord pathology suggests that the pathologic substrate may be neurochemical or receptor based. © 2004 Movement Disorder Society</div>
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Movement Disorders (revue)

Neuropathology of primary restless leg syndrome: Absence of specific τ‐ and α‐synuclein pathology

Neuropathology of primary restless leg syndrome: Absence of specific τ‐ and α‐synuclein pathology

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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